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TargetFarnesyl pyrophosphate synthase
LigandBDBM50115112
Substrate/Competitorn/a
Meas. Tech.ChEMBL_69840 (CHEMBL681891)
Ki 47±n/a nM
Citation Sanders, JMGómez, AOMao, JMeints, GAVan Brussel, EMBurzynska, AKafarski, PGonzález-Pacanowska, DOldfield, E 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. J Med Chem46:5171-83 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Farnesyl pyrophosphate synthase
Name:Farnesyl pyrophosphate synthase
Synonyms:Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:Enzyme
Mol. Mass.:48272.89
Organism:Homo sapiens (Human)
Description:P14324
Residue:419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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  Blast E-value cutoff:
BDBM50115112
n/a
NameBDBM50115112
Synonyms:(Bis-phosphono-methyl)-(3-methyl-butyl)-ammonium | (isopentylamino)methylenediphosphonic acid | CHEMBL55856 | [(3-Methyl-butylamino)-phosphono-methyl]-phosphonic acid | [[(3-methylbutyl)amino]methylene]-1,1-bisphosphonate
TypeSmall organic molecule
Emp. Form.C6H17NO6P2
Mol. Mass.261.1498
SMILESCC(C)CCN=C(P(O)(O)O)P(O)(O)=O |w:5.4|
Structure
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