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TargetFarnesyl pyrophosphate synthase
LigandBDBM50115104
Substrate/Competitorn/a
Meas. Tech.ChEMBL_69840 (CHEMBL681891)
Ki 20±n/a nM
Citation Sanders, JMGómez, AOMao, JMeints, GAVan Brussel, EMBurzynska, AKafarski, PGonzález-Pacanowska, DOldfield, E 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. J Med Chem46:5171-83 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Farnesyl pyrophosphate synthase
Name:Farnesyl pyrophosphate synthase
Synonyms:Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:Enzyme
Mol. Mass.:48272.89
Organism:Homo sapiens (Human)
Description:P14324
Residue:419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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  Blast E-value cutoff:
BDBM50115104
n/a
NameBDBM50115104
Synonyms:(pyridin-2-ylamino)methylenediphosphonic acid | 2-[(Bis-phosphono-methyl)-amino]-pyridinium | 2-{[hydrogen phosphonato(phosphonato)methyl]amino}pyridin-1-ium | CHEMBL291736 | [(2-pyridinylamino)methylene]-1,1-bisphosphonate | [Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic acid | [Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic acid(NE11807)
TypeSmall organic molecule
Emp. Form.C6H10N2O6P2
Mol. Mass.268.1009
SMILESOP(O)(=O)C(Nc1ccccn1)P(O)(O)=O
Structure
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