Reaction Details |
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Target | Farnesyl pyrophosphate synthase |
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Ligand | BDBM50098382 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_69839 (CHEMBL681890) |
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IC50 | 5400±n/a nM |
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Citation | Sanders, JM; Gómez, AO; Mao, J; Meints, GA; Van Brussel, EM; Burzynska, A; Kafarski, P; González-Pacanowska, D; Oldfield, E 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. J Med Chem46:5171-83 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Farnesyl pyrophosphate synthase |
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Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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BDBM50098382 |
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n/a |
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Name | BDBM50098382 |
Synonyms: | (1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phosphonic acid | (1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phosphonic acid(NE58051,homorisedronate) | 1-hydroxy-3-(pyridin-3-yl)propane-1,1-diyldiphosphonic acid | 3-(3-Hydroxy-3,3-bis-phosphono-propyl)-pyridinium | 3-(3-hydrogen phosphonato-3-hydroxy-3-phosphonatopropyl)pyridin-1-ium | 3-(3-pyridyl)-1-hydroxy-propane-1,1-bisphosphonate | CHEMBL293522 |
Type | Small organic molecule |
Emp. Form. | C8H13NO7P2 |
Mol. Mass. | 297.1388 |
SMILES | OC(CCc1cccnc1)(P(O)(O)=O)P(O)(O)=O |
Structure |
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