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TargetFarnesyl pyrophosphate synthase
LigandBDBM50098382
Substrate/Competitorn/a
Meas. Tech.ChEMBL_69839 (CHEMBL681890)
IC50 5400±n/a nM
Citation Sanders, JMGómez, AOMao, JMeints, GAVan Brussel, EMBurzynska, AKafarski, PGonzález-Pacanowska, DOldfield, E 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. J Med Chem46:5171-83 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Farnesyl pyrophosphate synthase
Name:Farnesyl pyrophosphate synthase
Synonyms:Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:Enzyme
Mol. Mass.:48272.89
Organism:Homo sapiens (Human)
Description:P14324
Residue:419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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  Blast E-value cutoff:
BDBM50098382
n/a
NameBDBM50098382
Synonyms:(1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phosphonic acid | (1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phosphonic acid(NE58051,homorisedronate) | 1-hydroxy-3-(pyridin-3-yl)propane-1,1-diyldiphosphonic acid | 3-(3-Hydroxy-3,3-bis-phosphono-propyl)-pyridinium | 3-(3-hydrogen phosphonato-3-hydroxy-3-phosphonatopropyl)pyridin-1-ium | 3-(3-pyridyl)-1-hydroxy-propane-1,1-bisphosphonate | CHEMBL293522
TypeSmall organic molecule
Emp. Form.C8H13NO7P2
Mol. Mass.297.1388
SMILESOC(CCc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Structure
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