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TargetThrombin-activable fibrinolysis inhibitor (TAFIa)
LigandBDBM50135939
Substrate/Competitorn/a
Meas. Tech.ChEMBL_45639
IC50 8.2±n/a nM
Citation Barrow JCNantermet PGStauffer SRNgo PLSteinbeiser MAMao SSCarroll SSBailey CColussi DBosserman MBurlein CCook JJSitko GTiller PRMiller-Stein CMRose MMcMasters DRVacca JPSelnick HG Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem 46:5294-7 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thrombin-activable fibrinolysis inhibitor (TAFIa)
Name:Carboxypeptidase B2 isoform A
Synonyms:CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:Enzyme
Mol. Mass.:48432.74
Organism:Homo sapiens (Human)
Description:Q96IY4
Residue:423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
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  Blast E-value cutoff:
BDBM50135939
n/a
NameBDBM50135939
Synonyms:3-(4,4-Diamino-but-3-enylsulfanyl)-2-mercaptomethyl-propionic acid | CHEMBL150332
TypeSmall organic molecule
Emp. Form.C8H16N2O2S2
Mol. Mass.236.355
SMILESNC(=N)CCCSCC(CS)C(O)=O
Structure
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