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TargetOrexin/Hypocretin receptor type 1
LigandBDBM50136698
Substrate/Competitorn/a
Meas. Tech.ChEBML_147674
IC50 3850±n/a nM
Citation Hirose, MEgashira, SGoto, YHashihayata, TOhtake, NIwaasa, HHata, MFukami, TKanatani, AYamada, K N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist. Bioorg Med Chem Lett13:4497-9 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Orexin/Hypocretin receptor type 1
Name:Orexin/Hypocretin receptor type 1
Synonyms:HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:Protein
Mol. Mass.:47554.50
Organism:Homo sapiens (Human)
Description:O43613
Residue:425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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  Blast E-value cutoff:
BDBM50136698
n/a
NameBDBM50136698
Synonyms:(S)-2-(benzylamino)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3,3-dimethylbutan-1-one | (S)-2-Benzylamino-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-butan-1-one | CHEMBL140348
TypeSmall organic molecule
Emp. Form.C24H32N2O3
Mol. Mass.396.5225
SMILESCOc1cc2CCN(Cc2cc1OC)C(=O)[C@@H](NCc1ccccc1)C(C)(C)C |r|
Structure
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