Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM50136699 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_147674 |
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IC50 | 1130±n/a nM |
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Citation | Hirose, M; Egashira, S; Goto, Y; Hashihayata, T; Ohtake, N; Iwaasa, H; Hata, M; Fukami, T; Kanatani, A; Yamada, K N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist. Bioorg Med Chem Lett13:4497-9 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM50136699 |
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n/a |
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Name | BDBM50136699 |
Synonyms: | (S)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-[(thiophen-2-ylmethyl)-amino]-butan-1-one | (S)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3,3-dimethyl-2-(thiophen-2-ylmethylamino)butan-1-one | CHEMBL344622 |
Type | Small organic molecule |
Emp. Form. | C22H30N2O3S |
Mol. Mass. | 402.55 |
SMILES | COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H](NCc1cccs1)C(C)(C)C |r| |
Structure |
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