Reaction Details | |||
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Target | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | ||
Ligand | BDBM50136906 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_103130 (CHEMBL712301) | ||
Ki | 2200±n/a nM | ||
Citation | Li, X; Chu, S; Feher, VA; Khalili, M; Nie, Z; Margosiak, S; Nikulin, V; Levin, J; Sprankle, KG; Tedder, ME; Almassy, R; Appelt, K; Yager, KM Structure-based design, synthesis, and antimicrobial activity of indazole-derived SAH/MTA nucleosidase inhibitors. J Med Chem46:5663-73 (2003) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | |||
Name: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | ||
Synonyms: | 5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | MTNN_ECOLI | Methylthioadenosine Nucleosidase(MTAN) | P46 | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs | yadA | ||
Type: | Enzyme | ||
Mol. Mass.: | 24347.14 | ||
Organism: | Escherichia coli (strain K12) | ||
Description: | P0AF12 | ||
Residue: | 232 | ||
Sequence: |
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BDBM50136906 | |||
n/a | |||
Name | BDBM50136906 | ||
Synonyms: | 4-Chloro-N-[3-chloro-7-(3-methyl-but-2-enylamino)-1H-indazol-5-yl]-benzenesulfonamide | CHEMBL356233 | ||
Type | Small organic molecule | ||
Emp. Form. | C18H18Cl2N4O2S | ||
Mol. Mass. | 425.332 | ||
SMILES | CC(C)=CCNc1cc(NS(=O)(=O)c2ccc(Cl)cc2)cc2c(Cl)[nH]nc12 |(1.06,-.29,;2.39,.47,;2.39,2.01,;3.72,-.29,;5.05,.48,;6.39,-.29,;6.4,-1.83,;5.07,-2.6,;5.07,-4.15,;3.74,-4.92,;3.74,-6.46,;2.2,-6.46,;5.28,-6.46,;3.74,-8,;2.41,-8.77,;2.41,-10.31,;3.74,-11.08,;3.74,-12.62,;5.09,-10.31,;5.09,-8.77,;6.4,-4.91,;7.75,-4.14,;9.2,-4.6,;9.97,-5.93,;10.11,-3.37,;9.2,-2.11,;7.75,-2.6,)| | ||
Structure |