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Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
LigandBDBM50136906
Substrate/Competitorn/a
Meas. Tech.ChEMBL_103130 (CHEMBL712301)
Ki 2200±n/a nM
Citation Li, XChu, SFeher, VAKhalili, MNie, ZMargosiak, SNikulin, VLevin, JSprankle, KGTedder, MEAlmassy, RAppelt, KYager, KM Structure-based design, synthesis, and antimicrobial activity of indazole-derived SAH/MTA nucleosidase inhibitors. J Med Chem46:5663-73 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Name:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | MTNN_ECOLI | Methylthioadenosine Nucleosidase(MTAN) | P46 | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs | yadA
Type:Enzyme
Mol. Mass.:24347.14
Organism:Escherichia coli (strain K12)
Description:P0AF12
Residue:232
Sequence:
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGAT
LLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFK
ADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAH
VCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
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  Blast E-value cutoff:
BDBM50136906
n/a
NameBDBM50136906
Synonyms:4-Chloro-N-[3-chloro-7-(3-methyl-but-2-enylamino)-1H-indazol-5-yl]-benzenesulfonamide | CHEMBL356233
TypeSmall organic molecule
Emp. Form.C18H18Cl2N4O2S
Mol. Mass.425.332
SMILESCC(C)=CCNc1cc(NS(=O)(=O)c2ccc(Cl)cc2)cc2c(Cl)[nH]nc12 |(1.06,-.29,;2.39,.47,;2.39,2.01,;3.72,-.29,;5.05,.48,;6.39,-.29,;6.4,-1.83,;5.07,-2.6,;5.07,-4.15,;3.74,-4.92,;3.74,-6.46,;2.2,-6.46,;5.28,-6.46,;3.74,-8,;2.41,-8.77,;2.41,-10.31,;3.74,-11.08,;3.74,-12.62,;5.09,-10.31,;5.09,-8.77,;6.4,-4.91,;7.75,-4.14,;9.2,-4.6,;9.97,-5.93,;10.11,-3.37,;9.2,-2.11,;7.75,-2.6,)|
Structure
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