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Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
LigandBDBM50136926
Substrate/Competitorn/a
Meas. Tech.ChEMBL_103130 (CHEMBL712301)
Ki 498.0±n/a nM
Citation Li, XChu, SFeher, VAKhalili, MNie, ZMargosiak, SNikulin, VLevin, JSprankle, KGTedder, MEAlmassy, RAppelt, KYager, KM Structure-based design, synthesis, and antimicrobial activity of indazole-derived SAH/MTA nucleosidase inhibitors. J Med Chem46:5663-73 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Name:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | MTNN_ECOLI | Methylthioadenosine Nucleosidase(MTAN) | P46 | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs | yadA
Type:Enzyme
Mol. Mass.:24347.14
Organism:Escherichia coli (strain K12)
Description:P0AF12
Residue:232
Sequence:
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGAT
LLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFK
ADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAH
VCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
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  Blast E-value cutoff:
BDBM50136926
n/a
NameBDBM50136926
Synonyms:Biphenyl-3-sulfonic acid (7-isobutylamino-3-methyl-1H-indazol-5-yl)-amide | CHEMBL153309
TypeSmall organic molecule
Emp. Form.C24H26N4O2S
Mol. Mass.434.554
SMILESCC(C)CNc1cc(NS(=O)(=O)c2cccc(c2)-c2ccccc2)cc2c(C)n[nH]c12
Structure
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