| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Matrix metalloproteinase-9 |
|---|
| Ligand | BDBM50137276 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_105527 |
|---|
| IC50 | 46±n/a nM |
|---|
| Citation |  Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett14:47-50 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Matrix metalloproteinase-9 |
|---|
| Name: | Matrix metalloproteinase-9 |
|---|
| Synonyms: | 67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | MMP9_HUMAN | Matrix metalloproteinase 9 (MMP-9) | Matrix metalloproteinase-9 (MMP-9) | Matrix metalloproteinase-9 (MMP9) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 78452.28 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14780 |
|---|
| Residue: | 707 |
|---|
| Sequence: | MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP
FDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRS
YSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYS
ACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYST
CTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMY
PMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSER
PTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYW
RFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRR
LDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLD
THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
|
|
|
|---|
| BDBM50137276 |
|---|
| n/a |
|---|
| Name | BDBM50137276 |
|---|
| Synonyms: | 6-Hydroxy-7-methoxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide | CHEMBL148214 | N,6-dihydroxy-7-methoxy-2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H20N2O7S |
|---|
| Mol. Mass. | 408.426 |
|---|
| SMILES | COc1ccc(cc1)S(=O)(=O)N1CCc2cc(O)c(OC)cc2C1C(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
