| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50137386 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48321 |
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| Ki | 12±n/a nM |
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| Citation |  Kim, TS; Hague, AB; Lee, TI; Lian, B; Tegley, CM; Wang, X; Burgess, TL; Qian, YX; Ross, S; Tagari, P; Lin, CH; Mayeda, C; Dao, J; Jordan, S; Mohr, C; Cheetham, J; Viswanadhan, V; Tasker, AS (4-Piperidinylphenyl)aminoethyl amides as a novel class of non-covalent cathepsin K inhibitors. Bioorg Med Chem Lett14:87-90 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50137386 |
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| n/a |
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| Name | BDBM50137386 |
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| Synonyms: | 2-{(S)-3-Phenyl-1-[(4-piperidin-1-yl-phenylamino)-methyl]-propylcarbamoyl}-pyrrolidine-1-carboxylic acid benzyl ester | CHEMBL170962 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H42N4O3 |
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| Mol. Mass. | 554.7223 |
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| SMILES | O=C(N[C@@H](CCc1ccccc1)CNc1ccc(cc1)N1CCCCC1)C1CCCN1C(=O)OCc1ccccc1 |
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| Structure | 
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