| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
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| Ligand | BDBM50137442 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_158583 |
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| IC50 | 9900±n/a nM |
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| Citation |  Li, J; DeMello, KM; Cheng, H; Sakya, SM; Bronk, BS; Rafka, RJ; Jaynes, BH; Ziegler, CB; Kilroy, C; Mann, DW; Nimz, EL; Lynch, MP; Haven, ML; Kolosko, NL; Minich, ML; Li, C; Dutra, JK; Rast, B; Crosson, RM; Morton, BJ; Kirk, GW; Callaghan, KM; Koss, DA; Shavnya, A; Lund, LA; Seibel, SB; Petras, CF; Silvia, A Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine. Bioorg Med Chem Lett14:95-8 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 1 |
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| Name: | Prostaglandin G/H synthase 1 |
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| Synonyms: | COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_CANLF | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69314.28 |
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| Organism: | Canis familiaris |
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| Description: | ChEMBL_327426 |
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| Residue: | 603 |
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| Sequence: | MSRGSRLHRWPLLLLLLLLLPPPPVLPAEARTPAPVNPCCYYPCQHQGICVRFGLDRYQC
DCTRTGYSGPNCTIPELWTWLRNSLRPSPSFLHFLLTHGRWFWEFINATFIRDMLMRLVL
TARSNLIPSPPTYNIAHDYISWESFSNVSYYTRVLPSVPQDCPTPMGTKGKKQLPDAQLL
GRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDN
LDRQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGILPQSQMAVGQEVFGLLPG
LMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFL
QLKFDPELLFSAQFQYRNRIAMEFNQLYHWHPLMPDSFWVGSQEYSYEQFLFNTSMLTHY
GIEALVDAFSRQSAGRIGGGRNIDHHVLHVAVETIKESRELRLQPFNEYRKRFGMRPYMS
FQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGN
PICSPEYWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFRVPDPHQDGGPGVERPS
TEL
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| BDBM50137442 |
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| n/a |
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| Name | BDBM50137442 |
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| Synonyms: | 2-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-pyrazol-1-yl]-5-methanesulfonyl-pyridine | CHEMBL174724 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14F3N3O3S |
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| Mol. Mass. | 397.372 |
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| SMILES | COc1ccc(cc1F)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F |
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| Structure | 
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