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TargetProstaglandin G/H synthase 2
LigandBDBM50137437
Substrate/Competitorn/a
Meas. Tech.ChEBML_159595
IC50 69.0±n/a nM
Citation Li, JDeMello, KMCheng, HSakya, SMBronk, BSRafka, RJJaynes, BHZiegler, CBKilroy, CMann, DWNimz, ELLynch, MPHaven, MLKolosko, NLMinich, MLLi, CDutra, JKRast, BCrosson, RMMorton, BJKirk, GWCallaghan, KMKoss, DAShavnya, ALund, LASeibel, SBPetras, CFSilvia, A Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine. Bioorg Med Chem Lett14:95-8 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin G/H synthase 2
Name:Prostaglandin G/H synthase 2
Synonyms:Cyclooxygenase-2 | Prostaglandin G/H synthase-2
Type:PROTEIN
Mol. Mass.:68982.35
Organism:Canis familiaris
Description:ChEMBL_344386
Residue:604
Sequence:
MLARALVLCAALAVVRAANPCCSHPCQNQGICMSTGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLYLKPTPNTVHYILTHFKGVWNIVNNIPFLRNTIMKYVLTSRSHLIESPPTYNVNY
GYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGKKELPDSKEIVEKFLLRRKFIPDPQGT
NMMFAFFAQHFTHQFFKTDHKRGPAFTKGLGHGVDLNHVYGETLDRQHKLRLFKDGKMKY
QVIDGEVYPPTVKDTQVEMIYPPHVPEHLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIAAEFNTLYHWHPLLPDTLQIDDQEYNFQQFIYNNSILLEHGLTQFVESFSRQIAGRV
AGGRNVPAAVQQVAKASIDQSRQMKYQSLNEYRKRFRLKPYTSFEELTGEKEMAAGLEAL
YGDIDAMELYPALLVEKPRPDAIFGETMVEMGAPFSLKGLMGNPICSPDYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTAFSVQDGQLTKTVTINASSSHSGLDDINPTVLLKER
STEL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50137437
n/a
NameBDBM50137437
Synonyms:5-Methanesulfonyl-2-[5-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-pyridine | CHEMBL367123
TypeSmall organic molecule
Emp. Form.C17H14F3N3O2S2
Mol. Mass.413.437
SMILESCSc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: