| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fyn |
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| Ligand | BDBM50137580 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_69578 |
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| IC50 | 700±n/a nM |
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| Citation |  Guan, H; Laird, AD; Blake, RA; Tang, C; Liang, C Design and synthesis of aminopropyl tetrahydroindole-based indolin-2-ones as selective and potent inhibitors of Src and Yes tyrosine kinase. Bioorg Med Chem Lett14:187-90 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Fyn |
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| Name: | Tyrosine-protein kinase Fyn |
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| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
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| Type: | Enzyme |
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| Mol. Mass.: | 60762.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06241 |
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| Residue: | 537 |
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| Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
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| BDBM50137580 |
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| n/a |
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| Name | BDBM50137580 |
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| Synonyms: | 3-[1-[3-(3-Morpholin-4-yl-propyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide | CHEMBL296185 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N4O4S |
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| Mol. Mass. | 484.611 |
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| SMILES | CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCOCC3)c2c1 |
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| Structure | 
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