| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50137861 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_163993 |
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| IC50 | 25000±n/a nM |
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| Citation |  Summa, V; Petrocchi, A; Pace, P; Matassa, VG; De Francesco, R; Altamura, S; Tomei, L; Koch, U; Neuner, P Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase. J Med Chem47:14-7 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50137861 |
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| n/a |
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| Name | BDBM50137861 |
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| Synonyms: | 2,4-Dioxo-4-(2-pentyloxy-phenyl)-butyric acid | CHEMBL426948 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18O5 |
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| Mol. Mass. | 278.3004 |
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| SMILES | CCCCCOc1ccccc1C(=O)CC(=O)C(O)=O |
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| Structure | 
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