| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V2 receptor |
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| Ligand | BDBM50137946 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_215011 |
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| IC50 | 4±n/a nM |
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| Citation |  Cho, H; Murakami, K; Nakanishi, H; Fujisawa, A; Isoshima, H; Niwa, M; Hayakawa, K; Hase, Y; Uchida, I; Watanabe, H; Wakitani, K; Aisaka, K Synthesis and structure-activity relationships of 5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine derivatives: novel arginine vasopressin antagonists. J Med Chem47:101-9 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V2 receptor |
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| Name: | Vasopressin V2 receptor |
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| Synonyms: | AVPR V2 | Antidiuretic hormone receptor | Avpr2 | Renal-type arginine vasopressin receptor | V2R_RAT | VASOPRESSIN V2 | Vasopressin receptor |
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| Type: | G-protein coupled receptor |
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| Mol. Mass.: | 40761.85 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | n/a |
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| Residue: | 371 |
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| Sequence: | MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLG
ALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQ
RDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGP
SERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEA
PLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCAT
ASSSLMKDTPS
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| BDBM50137946 |
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| n/a |
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| Name | BDBM50137946 |
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| Synonyms: | Biphenyl-2-carboxylic acid [2-[2-(4-dimethylamino-piperidin-1-yl)-2-oxo-ethoxy]-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide | CHEMBL177885 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H40N4O4S |
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| Mol. Mass. | 636.803 |
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| SMILES | CN(C)C1CCN(CC1)C(=O)COc1cc(ccc1NC(=O)c1ccccc1-c1ccccc1)C(=O)N1CCCCc2sccc12 |
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| Structure | 
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