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TargetVasopressin V1a/V1b receptor
LigandBDBM50137942
Substrate/Competitorn/a
Meas. Tech.ChEMBL_214265 (CHEMBL821106)
IC50 20±n/a nM
Citation Cho, HMurakami, KNakanishi, HFujisawa, AIsoshima, HNiwa, MHayakawa, KHase, YUchida, IWatanabe, HWakitani, KAisaka, K Synthesis and structure-activity relationships of 5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine derivatives: novel arginine vasopressin antagonists. J Med Chem47:101-9 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vasopressin V1a/V1b receptor
Name:Vasopressin V1a/V1b receptor
Synonyms:Vasopressin V1 receptor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 214265
Components:This complex has 2 components.
Component 1
Name:Vasopressin V1a receptor
Synonyms:Avpr1a | V1AR_RAT | VASOPRESSIN V1A | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:47674.81
Organism:RAT
Description:VASOPRESSIN V1A AVPR1A RAT::P30560
Residue:424
Sequence:
MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAV
IFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGP
DWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFI
LSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGF
ICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTF
VIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGH
LLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFI
PVST
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Component 2
Name:Vasopressin V1b receptor
Synonyms:Avpr1b | V1BR_RAT | VASOPRESSIN V1B | Vasopressin V1b receptor | Vasopressin receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:47104.48
Organism:RAT
Description:VASOPRESSIN V1B AVPR1B RAT::P48974
Residue:425
Sequence:
MNSEPSWTATPSPGGTLPVPNATTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLTLG
RHGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFA
STYMLLAMTLDRYLAVCHPLRSLRQPSQSTYPLIAAPWLLAAILSLPQVFIFSLREVIQG
SGVLDCWADFYFSWGPRAYITWTTMAIFVLPVAVLSACYGLICHEIYKNLKVKTQAGREE
RRGWRTWDKSSSSAVATAATRGLPSRVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFS
VQMWSVWDENAPNEDSTNVAFTISMLLGNLSSCCNPWIYMGFNSRLLPRSLSHHACCTGS
KPQVHRQLSTSSLTSRRTTLLTHACGSPTLRLSLNLSLRAKPRPAGSLKDLEQVDGEATM
ETSIF
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BDBM50137942
n/a
NameBDBM50137942
Synonyms:Biphenyl-2-carboxylic acid [2-(4-[1,4']bipiperidinyl-1'-yl-4-oxo-butoxy)-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide | CHEMBL368353
TypeSmall organic molecule
Emp. Form.C42H48N4O4S
Mol. Mass.704.92
SMILESO=C(CCCOc1cc(ccc1NC(=O)c1ccccc1-c1ccccc1)C(=O)N1CCCCc2sccc12)N1CCC(CC1)N1CCCCC1
Structure
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