Reaction Details |
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Target | Nitric oxide synthase, brain |
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Ligand | BDBM50225106 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_143499 |
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IC50 | 500±n/a nM |
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Citation | Ueda, S; Terauchi, H; Yano, A; Ido, M; Matsumoto, M; Kawasaki, M 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett14:313-6 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Nitric oxide synthase, brain |
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Name: | Nitric oxide synthase, brain |
Synonyms: | Constitutive NOS | N-NOS | NC-NOS | NOS type I | NOS1_MOUSE | Neuronal NOS | Nitric-oxide synthase, brain | Nos1 | bNOS |
Type: | PROTEIN |
Mol. Mass.: | 160483.95 |
Organism: | Mus musculus |
Description: | ChEMBL_143499 |
Residue: | 1429 |
Sequence: | MEEHTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTQPLGTPTKAVDLSRQPSASKDQPLAVDRVPGPSNGPQHAQGRGQGAGSVSQANGVAI
DPTMKNTKANLQDSGEQDELLKEIEPVLSILTGGGKAVNRGGPAKAEMKDTGIQVDRDLD
GKLHKAPPLGGENDRVFNDLWGKGNVPVVLNNPYSENEQSPASGKQSPTKNGSPSRCPRF
LKVKNWETDVVLTDTLHLKSTLETGCTEQICMGSIMLPSHHIRKSEDVRTKDQLFPLAKE
FLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQ
WSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLI
RYAGYKQPDGSTLGDPANVEFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPEL
VLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCD
NSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIK
HMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTN
GTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHA
FDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKS
YKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVD
TLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISN
DRSWKRNKFRLTYVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTN
GNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWK
DESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKW
GKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTR
DGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFW
QQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPK
KYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVF
ISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
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BDBM50225106 |
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n/a |
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Name | BDBM50225106 |
Synonyms: | (2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino}pentanoic acid | (2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino}pentanoic acid]] | (2S)-2-amino-5-{[(E)-imino(nitroamino)methyl]amino}pentanoic acid | (2S)-2-amino-5-{[imino(nitroamino)methyl]amino}pentanoic acid | (S)-2-Amino-5-(N'-nitro-guanidino)-pentanoic acid | 2-Amino-5-(N'-nitro-guanidino)-pentanoic acid | CHEMBL227744 | N-OMEGA-NITRO-L-ARGININE | N-nitro-L-arginine | NG-nitroarginine | Ngamma-nitro-L-arginine | Nomega-nitro-L-arginine |
Type | Small organic molecule |
Emp. Form. | C6H13N5O4 |
Mol. Mass. | 219.1985 |
SMILES | N[C@@H](CCCNC(N)=N[N+]([O-])=O)C(O)=O |r,w:8.8| |
Structure |
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