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TargetNitric oxide synthase, brain
LigandBDBM50225106
Substrate/Competitorn/a
Meas. Tech.ChEBML_143499
IC50 500±n/a nM
Citation Ueda, STerauchi, HYano, AIdo, MMatsumoto, MKawasaki, M 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett14:313-6 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Nitric oxide synthase, brain
Name:Nitric oxide synthase, brain
Synonyms:Constitutive NOS | N-NOS | NC-NOS | NOS type I | NOS1_MOUSE | Neuronal NOS | Nitric-oxide synthase, brain | Nos1 | bNOS
Type:PROTEIN
Mol. Mass.:160483.95
Organism:Mus musculus
Description:ChEMBL_143499
Residue:1429
Sequence:
MEEHTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTQPLGTPTKAVDLSRQPSASKDQPLAVDRVPGPSNGPQHAQGRGQGAGSVSQANGVAI
DPTMKNTKANLQDSGEQDELLKEIEPVLSILTGGGKAVNRGGPAKAEMKDTGIQVDRDLD
GKLHKAPPLGGENDRVFNDLWGKGNVPVVLNNPYSENEQSPASGKQSPTKNGSPSRCPRF
LKVKNWETDVVLTDTLHLKSTLETGCTEQICMGSIMLPSHHIRKSEDVRTKDQLFPLAKE
FLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQ
WSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLI
RYAGYKQPDGSTLGDPANVEFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPEL
VLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCD
NSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIK
HMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTN
GTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHA
FDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKS
YKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVD
TLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISN
DRSWKRNKFRLTYVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTN
GNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWK
DESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKW
GKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTR
DGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFW
QQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPK
KYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVF
ISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
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BDBM50225106
n/a
NameBDBM50225106
Synonyms:(2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino}pentanoic acid | (2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino}pentanoic acid]] | (2S)-2-amino-5-{[(E)-imino(nitroamino)methyl]amino}pentanoic acid | (2S)-2-amino-5-{[imino(nitroamino)methyl]amino}pentanoic acid | (S)-2-Amino-5-(N'-nitro-guanidino)-pentanoic acid | 2-Amino-5-(N'-nitro-guanidino)-pentanoic acid | CHEMBL227744 | N-OMEGA-NITRO-L-ARGININE | N-nitro-L-arginine | NG-nitroarginine | Ngamma-nitro-L-arginine | Nomega-nitro-L-arginine
TypeSmall organic molecule
Emp. Form.C6H13N5O4
Mol. Mass.219.1985
SMILESN[C@@H](CCCNC(N)=N[N+]([O-])=O)C(O)=O |r,w:8.8|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: