| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50138521 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_29728 |
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| Ki | 96±n/a nM |
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| Citation |  Palle, VP; Varkhedkar, V; Ibrahim, P; Ahmed, H; Li, Z; Gao, Z; Ozeck, M; Wu, Y; Zeng, D; Wu, L; Leung, K; Chu, N; Zablocki, JA Affinity and intrinsic efficacy (IE) of 5'-carbamoyl adenosine analogues for the A1 adenosine receptor--efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF). Bioorg Med Chem Lett14:535-9 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36520.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30542 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
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| BDBM50138521 |
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| n/a |
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| Name | BDBM50138521 |
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| Synonyms: | CHEMBL149790 | Methyl-carbamic acid (2R,3S,4R)-5-{2-chloro-6-[(R)-(tetrahydro-furan-3-yl)amino]-purin-9-yl}-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21ClN6O6 |
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| Mol. Mass. | 428.828 |
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| SMILES | CNC(=O)OC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(NC3CCOC3)nc(Cl)nc12 |
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| Structure | 
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