| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisomal acyl-coenzyme A oxidase 1 |
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| Ligand | BDBM50138618 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_154606 |
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| IC50 | 2000±n/a nM |
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| Citation |  Koltun, DO; Marquart, TA; Shenk, KD; Elzein, E; Li, Y; Nguyen, M; Kerwar, S; Zeng, D; Chu, N; Soohoo, D; Hao, J; Maydanik, VY; Lustig, DA; Ng, KJ; Fraser, H; Zablocki, JA New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties. Bioorg Med Chem Lett14:549-52 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisomal acyl-coenzyme A oxidase 1 |
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| Name: | Peroxisomal acyl-coenzyme A oxidase 1 |
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| Synonyms: | ACOX1_RAT | AOX | Acox | Acox1 | Palmitoyl-CoA oxidase | Peroxisomal acyl-CoA oxidase 1, A chain | Peroxisomal acyl-CoA oxidase 1, B chain | Peroxisomal acyl-CoA oxidase 1, C chain | Peroxisomal acyl-coenzyme A oxidase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74693.04 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_311972 |
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| Residue: | 661 |
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| Sequence: | MNPDLRKERASATFNPELITHILDGSPENTRRRREIENLILNDPDFQHEDYNFLTRSQRY
EVAVKKSATMVKKMREYGISDPEEIMWFKKLYLANFVEPVGLNYSMFIPTLLNQGTTAQQ
EKWMRPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTSIKWWPGGL
GKTSNHAIVLAQLITQGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGYEEMDNGYL
KMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGNAAQSLSKACTIA
IRYSAVRRQSEIKQSEPEPQILDFQTQQYKLFPLLATAYAFHFVGRYMKETYLRINESIG
QGDLSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTF
EGENTVMMLQTARFLMKIYDQVRSGKLVGGMVSYLNDLPSQRIQPQQVAVWPTMVDINSL
EGLTEAYKLRAARLVEIAAKNLQTHVSHRKSKEVAWNLTSVDLVRASEAHCHYVVVKVFS
DKLPKIQDKAVQAVLRNLCLLYSLYGISQKGGDFLEGSIITGAQLSQVNARILELLTLIR
PNAVALVDAFDFKDMTLGSVLGRYDGNVYENLFEWAKKSPLNKTEVHESYHKHLKPLQSK
L
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| BDBM50138618 |
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| n/a |
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| Name | BDBM50138618 |
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| Synonyms: | CHEMBL152844 | N-[4-(4-Chloro-phenoxy)-phenyl]-2-{4-[(R)-2-hydroxy-3-(2-methyl-benzothiazol-5-yloxy)-propyl]-piperazin-1-yl}-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31ClN4O4S |
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| Mol. Mass. | 567.099 |
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| SMILES | Cc1nc2cc(OC[C@H](O)CN3CCN(CC(=O)Nc4ccc(Oc5ccc(Cl)cc5)cc4)CC3)ccc2s1 |
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| Structure | 
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