Reaction Details |
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Target | Tissue-type plasminogen activator |
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Ligand | BDBM50138674 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_208066 (CHEMBL814417) |
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Ki | 3390±n/a nM |
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Citation | Wendt, MD; Rockway, TW; Geyer, A; McClellan, W; Weitzberg, M; Zhao, X; Mantei, R; Nienaber, VL; Stewart, K; Klinghofer, V; Giranda, VL Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution. J Med Chem47:303-24 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tissue-type plasminogen activator |
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Name: | Tissue-type plasminogen activator |
Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
Type: | Enzyme |
Mol. Mass.: | 62931.08 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 562 |
Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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BDBM50138674 |
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n/a |
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Name | BDBM50138674 |
Synonyms: | 6-Carbamimidoyl-naphthalene-2-carboxylic acid (3-cyclopentyloxy-phenyl)-amide | 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE | 6-carbamimidoyl-N-(3-(cyclopentyloxy)phenyl)-2-naphthamide | CHEMBL111575 |
Type | Small organic molecule |
Emp. Form. | C23H23N3O2 |
Mol. Mass. | 373.4476 |
SMILES | NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1cccc(OC2CCCC2)c1 |
Structure |
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