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TargetUrokinase-type plasminogen activator
LigandBDBM50138681
Substrate/Competitorn/a
Meas. Tech.ChEMBL_213154 (CHEMBL815981)
Ki 104±n/a nM
Citation Wendt, MDRockway, TWGeyer, AMcClellan, WWeitzberg, MZhao, XMantei, RNienaber, VLStewart, KKlinghofer, VGiranda, VL Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution. J Med Chem47:303-24 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Urokinase-type plasminogen activator
Name:Urokinase-type plasminogen activator
Synonyms:PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:Enzyme
Mol. Mass.:48528.62
Organism:Homo sapiens (Human)
Description:P00749
Residue:431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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  Blast E-value cutoff:
BDBM50138681
n/a
NameBDBM50138681
Synonyms:6-Carbamimidoyl-naphthalene-2-carboxylic acid [3-(1-ethyl-propoxy)-phenyl]-amide | CHEMBL111629
TypeSmall organic molecule
Emp. Form.C23H25N3O2
Mol. Mass.375.4635
SMILESCCC(CC)Oc1cccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)c1
Structure
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