| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil collagenase |
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| Ligand | BDBM50138683 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_105074 (CHEMBL711319) |
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| Ki | 18400±n/a nM |
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| Citation |  Matziari, M; Beau, F; Cuniasse, P; Dive, V; Yiotakis, A Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11. J Med Chem47:325-36 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil collagenase |
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| Name: | Neutrophil collagenase |
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| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
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| Type: | Enzyme |
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| Mol. Mass.: | 53413.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22894 |
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| Residue: | 467 |
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| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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| BDBM50138683 |
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| n/a |
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| Name | BDBM50138683 |
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| Synonyms: | (1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{3-(2-bromo-phenylsulfanyl)-2-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-propyl}-phosphinic acid | CHEMBL327108 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H38BrN4O6PS |
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| Mol. Mass. | 777.664 |
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| SMILES | NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CSc1ccccc1Br)CP(O)(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1 |
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| Structure | 
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