Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50138823 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_205881 (CHEMBL813942) |
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Ki | 2.94±n/a nM |
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Citation | Albert, JS; Ohnmacht, C; Bernstein, PR; Rumsey, WL; Aharony, D; Alelyunas, Y; Russell, DJ; Potts, W; Sherwood, SA; Shen, L; Dedinas, RF; Palmer, WE; Russell, K Structural analysis and optimization of NK(1) receptor antagonists through modulation of atropisomer interconversion properties. J Med Chem47:519-29 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50138823 |
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n/a |
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Name | BDBM50138823 |
Synonyms: | 3-Cyano-2-ethyl-naphthalene-1-carboxylic acid ((S)-2-(3,4-dichloro-phenyl)-4-{4-[2-((S)-methanesulfinyl)-phenyl]-piperidin-1-yl}-butyl)-methyl-amide | CHEMBL149326 |
Type | Small organic molecule |
Emp. Form. | C37H39Cl2N3O2S |
Mol. Mass. | 660.695 |
SMILES | CCc1c(cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(CC1)c1ccccc1[S@](C)=O)c1ccc(Cl)c(Cl)c1)C#N |
Structure |
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