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TargetMelanocortin receptor 5
LigandBDBM50139028
Substrate/Competitorn/a
Meas. Tech.ChEMBL_106654 (CHEMBL712999)
Ki 1400±n/a nM
Citation Richardson, TIOrnstein, PLBriner, KFisher, MJBacker, RTBiggers, CKClay, MPEmmerson, PJHertel, LWHsiung, HMHusain, SKahl, SDLee, JALindstrom, TDMartinelli, MJMayer, JPMullaney, JTO'Brien, TPPawlak, JMRevell, KDShah, JZgombick, JMHerr, RJMelekhov, ASampson, PBKing, CH Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor. J Med Chem47:744-55 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 5
Name:Melanocortin receptor 5
Synonyms:MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:Enzyme
Mol. Mass.:36612.92
Organism:Homo sapiens (Human)
Description:P33032
Residue:325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD
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  Blast E-value cutoff:
BDBM50139028
n/a
NameBDBM50139028
Synonyms:(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-dimethylaminomethyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide | 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-dimethylaminomethyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide | CHEMBL349850
TypeSmall organic molecule
Emp. Form.C32H38ClN5O2
Mol. Mass.560.129
SMILESCN(C)Cc1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1
Structure
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