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TargetMelanocortin receptor 4
LigandBDBM50139037
Substrate/Competitorn/a
Meas. Tech.ChEMBL_106179 (CHEMBL714598)
Ki 2400±n/a nM
Citation Richardson, TIOrnstein, PLBriner, KFisher, MJBacker, RTBiggers, CKClay, MPEmmerson, PJHertel, LWHsiung, HMHusain, SKahl, SDLee, JALindstrom, TDMartinelli, MJMayer, JPMullaney, JTO'Brien, TPPawlak, JMRevell, KDShah, JZgombick, JMHerr, RJMelekhov, ASampson, PBKing, CH Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor. J Med Chem47:744-55 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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  Blast E-value cutoff:
BDBM50139037
n/a
NameBDBM50139037
Synonyms:1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-nitro-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide | CHEMBL167780
TypeSmall organic molecule
Emp. Form.C29H30ClN5O4
Mol. Mass.548.033
SMILES[O-][N+](=O)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1
Structure
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