| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin D |
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| Ligand | BDBM50139109 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_45323 |
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| Ki | 2200±n/a nM |
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| Citation |  Brady, SF; Singh, S; Crouthamel, MC; Holloway, MK; Coburn, CA; Garsky, VM; Bogusky, M; Pennington, MW; Vacca, JP; Hazuda, D; Lai, MT Rational design and synthesis of selective BACE-1 inhibitors. Bioorg Med Chem Lett14:601-4 (2004) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin D |
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| Name: | Cathepsin D |
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| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 44551.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
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| Residue: | 412 |
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| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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| BDBM50139109 |
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| n/a |
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| Name | BDBM50139109 |
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| Synonyms: | (S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-isobutylcarbamoyl-hexyl)-2-(3-methyl-butyrylamino)-succinamic acid | CHEMBL154897 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H45N3O8 |
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| Mol. Mass. | 563.6829 |
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| SMILES | CC(C)CNC(=O)[C@H](CCOC(C)=O)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)C[C@H](NC(=O)CC(C)C)C(O)=O |
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| Structure | 
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