| Reaction Details |
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 | Report a problem with these data |
| Target | Plasminogen activator inhibitor 1 |
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| Ligand | BDBM50139534 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_155740 |
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| IC50 | 500±n/a nM |
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| Citation |  Ye, B; Chou, YL; Karanjawala, R; Lee, W; Lu, SF; Shaw, KJ; Jones, S; Lentz, D; Liang, A; Tseng, JL; Wu, Q; Zhao, Z Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1). Bioorg Med Chem Lett14:761-5 (2004) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasminogen activator inhibitor 1 |
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| Name: | Plasminogen activator inhibitor 1 |
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| Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 45064.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05121 |
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| Residue: | 402 |
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| Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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| BDBM50139534 |
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| n/a |
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| Name | BDBM50139534 |
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| Synonyms: | 2-[2-Methoxy-6-({3-trifluoromethyl-4-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-phenylamino}-methyl)-phenoxy]-5-nitro-benzoic acid | CHEMBL349130 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H28F6N4O6 |
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| Mol. Mass. | 690.589 |
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| SMILES | COc1cccc(CNc2ccc(N3CCN(CC3)c3cccc(c3)C(F)(F)F)c(c2)C(F)(F)F)c1Oc1ccc(cc1C(O)=O)[N+]([O-])=O |
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| Structure | 
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