| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin K-dependent protein C |
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| Ligand | BDBM50140380 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_27868 |
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| IC50 | >10000±n/a nM |
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| Citation |  Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs. Bioorg Med Chem Lett14:1221-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin K-dependent protein C |
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| Name: | Vitamin K-dependent protein C |
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| Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 52067.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 461 |
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| Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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| BDBM50140380 |
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| n/a |
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| Name | BDBM50140380 |
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| Synonyms: | 2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-aminomethyl-3-fluoro-biphenyl-4-yl)-amide | CHEMBL20934 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H22F2N4O |
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| Mol. Mass. | 468.4973 |
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| SMILES | Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2CN)n(n1)-c1cc2ccccc2cc1F |
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| Structure | 
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