Reaction Details |
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Target | C-X-C chemokine receptor type 1 |
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Ligand | BDBM50140791 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_44673 (CHEMBL656546) |
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IC50 | 2600±n/a nM |
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Citation | Widdowson, KL; Elliott, JD; Veber, DF; Nie, H; Rutledge, MC; McCleland, BW; Xiang, JN; Jurewicz, AJ; Hertzberg, RP; Foley, JJ; Griswold, DE; Martin, L; Lee, JM; White, JR; Sarau, HM Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. J Med Chem47:1319-21 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-X-C chemokine receptor type 1 |
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Name: | C-X-C chemokine receptor type 1 |
Synonyms: | C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2 |
Type: | Enzyme |
Mol. Mass.: | 39803.83 |
Organism: | Homo sapiens (Human) |
Description: | P25024 |
Residue: | 350 |
Sequence: | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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BDBM50140791 |
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n/a |
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Name | BDBM50140791 |
Synonyms: | 1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-phenyl)-urea | CHEMBL28009 |
Type | Small organic molecule |
Emp. Form. | C14H9Br2N3O2 |
Mol. Mass. | 411.048 |
SMILES | Oc1c(NC(=O)Nc2ccccc2Br)ccc(C#N)c1Br |
Structure |
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