| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50141467 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63695 (CHEMBL670651) |
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| IC50 | 78.0±n/a nM |
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| Citation |  Takahashi, H; Ohtake, N; Sakamoto, T; Iino, T; Kawanishi, N; Nakamura, M; Yoshizumi, T; Niiyama, K; Ozaki, S; Okada, H; Kano, A; Takahashi, H; Ishii, Y; Okada, M; Saito, M; Sawazaki, Y; Hayama, T; Nishikibe, M Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines. Bioorg Med Chem Lett14:1503-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49664.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
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| Residue: | 442 |
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| Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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| BDBM50141467 |
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| n/a |
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| Name | BDBM50141467 |
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| Synonyms: | (5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2-hydroxy-1-methyl-ethoxy)-4-methoxy-phenyl]-2-isopropylamino-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid | CHEMBL289216 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N2O7 |
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| Mol. Mass. | 520.5736 |
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| SMILES | COc1ccc([C@H]2[C@@H]([C@H](c3ccc(NC(C)C)nc23)c2ccc3OCOc3c2)C(O)=O)c(OC(C)CO)c1 |
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| Structure | 
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