Reaction Details |
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Target | Endothelin receptor type B |
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Ligand | BDBM50141471 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63695 |
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IC50 | 43±n/a nM |
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Citation | Takahashi, H; Ohtake, N; Sakamoto, T; Iino, T; Kawanishi, N; Nakamura, M; Yoshizumi, T; Niiyama, K; Ozaki, S; Okada, H; Kano, A; Takahashi, H; Ishii, Y; Okada, M; Saito, M; Sawazaki, Y; Hayama, T; Nishikibe, M Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines. Bioorg Med Chem Lett14:1503-7 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin receptor type B |
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Name: | Endothelin receptor type B |
Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49664.00 |
Organism: | Homo sapiens (Human) |
Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
Residue: | 442 |
Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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BDBM50141471 |
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n/a |
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Name | BDBM50141471 |
Synonyms: | (5S,6R,7R)-7-{2-[(Acetyl-methyl-amino)-methyl]-4-methoxy-phenyl}-5-benzo[1,3]dioxol-5-yl-2-isopropylamino-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid | CHEMBL37427 |
Type | Small organic molecule |
Emp. Form. | C30H33N3O6 |
Mol. Mass. | 531.5995 |
SMILES | COc1ccc([C@H]2[C@@H]([C@H](c3ccc(NC(C)C)nc23)c2ccc3OCOc3c2)C(O)=O)c(CN(C)C(C)=O)c1 |
Structure |
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