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TargetEndothelin-1 receptor
LigandBDBM50141465
Substrate/Competitorn/a
Meas. Tech.ChEBML_65489
IC50 0.022000±n/a nM
Citation Takahashi, HOhtake, NSakamoto, TIino, TKawanishi, NNakamura, MYoshizumi, TNiiyama, KOzaki, SOkada, HKano, ATakahashi, HIshii, YOkada, MSaito, MSawazaki, YHayama, TNishikibe, M Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines. Bioorg Med Chem Lett14:1503-7 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelin-1 receptor
Name:Endothelin-1 receptor
Synonyms:EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:Enzyme Catalytic Domain
Mol. Mass.:48736.88
Organism:Homo sapiens (Human)
Description:P25101
Residue:427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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  Blast E-value cutoff:
BDBM50141465
n/a
NameBDBM50141465
Synonyms:(5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(3-hydroxy-propyl)-4-methoxy-phenyl]-2-isopropylamino-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid | CHEMBL35984
TypeSmall organic molecule
Emp. Form.C29H32N2O6
Mol. Mass.504.5742
SMILESCOc1ccc([C@H]2[C@@H]([C@H](c3ccc(NC(C)C)nc23)c2ccc3OCOc3c2)C(O)=O)c(CCCO)c1
Structure
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