| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor receptor superfamily member 1A |
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| Ligand | BDBM50141494 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_224214 |
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| IC50 | 2000±n/a nM |
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| Citation |  Meng, CQ; Zheng, XS; Ni, L; Ye, Z; Simpson, JE; Worsencroft, KJ; Hotema, MR; Weingarten, MD; Skudlarek, JW; Gilmore, JM; Hoong, LK; Hill, RR; Marino, EM; Suen, KL; Kunsch, C; Wasserman, MA; Sikorski, JA Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-alpha-induced VCAM-1 expression. Bioorg Med Chem Lett14:1513-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor receptor superfamily member 1A |
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| Name: | Tumor necrosis factor receptor superfamily member 1A |
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| Synonyms: | CD_antigen=CD120a | TBPI | TNF-R1 | TNF-RI | TNFAR | TNFR-I | TNFR1 | TNFRSF1A | TNR1A_HUMAN | Tumor necrosis factor receptor R1 | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, membrane form | Tumor necrosis factor-binding protein 1 | p55 | p60 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50495.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1509419 |
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| Residue: | 455 |
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| Sequence: | MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
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| BDBM50141494 |
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| n/a |
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| Name | BDBM50141494 |
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| Synonyms: | (E)-1-[3,5-Dimethoxy-4-(3-methoxy-benzo[1,4]dioxin-2-yl)-phenyl]-3-(3,4,5-trimethoxy-phenyl)-propenone | CHEMBL435172 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28O9 |
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| Mol. Mass. | 520.5272 |
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| SMILES | COC1=C(Oc2ccccc2O1)c1c(OC)cc(cc1OC)C(=O)\C=C\c1cc(OC)c(OC)c(OC)c1 |t:2| |
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| Structure | 
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