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TargetTumor necrosis factor receptor superfamily member 1A
LigandBDBM50141536
Substrate/Competitorn/a
Meas. Tech.ChEBML_224214
IC50 1000±n/a nM
Citation Meng, CQZheng, XSNi, LYe, ZSimpson, JEWorsencroft, KJHotema, MRWeingarten, MDSkudlarek, JWGilmore, JMHoong, LKHill, RRMarino, EMSuen, KLKunsch, CWasserman, MASikorski, JA Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-alpha-induced VCAM-1 expression. Bioorg Med Chem Lett14:1513-7 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tumor necrosis factor receptor superfamily member 1A
Name:Tumor necrosis factor receptor superfamily member 1A
Synonyms:CD_antigen=CD120a | TBPI | TNF-R1 | TNF-RI | TNFAR | TNFR-I | TNFR1 | TNFRSF1A | TNR1A_HUMAN | Tumor necrosis factor receptor R1 | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, membrane form | Tumor necrosis factor-binding protein 1 | p55 | p60
Type:PROTEIN
Mol. Mass.:50495.39
Organism:Homo sapiens (Human)
Description:ChEMBL_1509419
Residue:455
Sequence:
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50141536
n/a
NameBDBM50141536
Synonyms:CHEMBL39896 | {4-[(E)-3-(3,4-Dimethoxy-5-thiophen-2-yl-phenyl)-acryloyl]-2,6-dimethoxy-phenoxy}-acetic acid
TypeSmall organic molecule
Emp. Form.C25H24O8S
Mol. Mass.484.518
SMILESCOc1cc(\C=C\C(=O)c2cc(OC)c(OCC(O)=O)c(OC)c2)cc(-c2cccs2)c1OC
Structure
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