| Reaction Details |
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 | Report a problem with these data |
| Target | ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial |
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| Ligand | BDBM50142258 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65930 (CHEMBL679205) |
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| IC50 | 77±n/a nM |
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| Citation |  Hamann, LG; Ding, CZ; Miller, AV; Madsen, CS; Wang, P; Stein, PD; Pudzianowski, AT; Green, DW; Monshizadegan, H; Atwal, KS Benzodiazepine-based selective inhibitors of mitochondrial F1F0 ATP hydrolase. Bioorg Med Chem Lett14:1031-4 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial |
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| Name: | ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial |
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| Synonyms: | Mitochondrial complex V; ATP synthase |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 65924 |
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| Components: | This complex has 4 components. |
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| Component 1 |
| Name: | ATP synthase subunit epsilon, mitochondrial |
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| Synonyms: | ATP5E | ATP5E_BOVIN | ATP5F1E | ATPase subunit epsilon |
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| Type: | PROTEIN |
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| Mol. Mass.: | 5790.87 |
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| Organism: | Bos taurus |
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| Description: | EBI_100264 |
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| Residue: | 51 |
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| Sequence: | MVAYWRQAGLSYIRYSQICAKAVRDALKTEFKANAMKTSGSTIKIVKVKKE
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| Component 2 |
| Name: | ATP synthase subunit beta, mitochondrial |
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| Synonyms: | ATP5B | ATP5F1B | ATPB_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56271.25 |
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| Organism: | Bos taurus |
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| Description: | EBI_100264 |
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| Residue: | 528 |
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| Sequence: | MLGLVGRVVAASASGALRGLSPSAPLPQAQLLLRAAPAALQPARDYAAQASPSPKAGATT
GRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLV
RGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPIKTKQFAAIHAEAPEFVEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERT
REGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQD
VLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAI
YVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDV
ARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHLGK
LVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHS
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| Component 3 |
| Name: | ATP synthase subunit gamma, mitochondrial |
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| Synonyms: | ATP5C | ATP5C1 | ATP5F1C | ATPG_BOVIN | F-ATPase gamma subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33081.70 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_65923 |
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| Residue: | 298 |
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| Sequence: | MFSRAGVAGLSAWTVQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAE
RELKPARVYGVGSLALYEKADIKTPEDKKKHLIIGVSSDRGLCGAIHSSVAKQMKSEAAN
LAAAGKEVKIIGVGDKIRSILHRTHSDQFLVTFKEVGRRPPTFGDASVIALELLNSGYEF
DEGSIIFNRFRSVISYKTEEKPIFSLDTISSAESMSIYDDIDADVLRNYQEYSLANIIYY
SLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
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| Component 4 |
| Name: | ATP synthase subunit delta, mitochondrial |
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| Synonyms: | ATP5D | ATP5F1D | ATPD_BOVIN | F-ATPase delta subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 17608.84 |
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| Organism: | Bos taurus |
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| Description: | EBI_100264 |
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| Residue: | 168 |
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| Sequence: | MLPSALLRRPGLGRLVRQVRLYAEAAAAQAPAAGPGQMSFTFASPTQVFFNSANVRQVDV
PTQTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSVTVNADSSVQLLAEEAV
TLDMLDLGAAKANLEKAQSELLGAADEATRAEIQIRIEANEALVKALE
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| BDBM50142258 |
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| n/a |
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| Name | BDBM50142258 |
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| Synonyms: | 4-(4-tert-Butyl-benzenesulfonyl)-1-(5-methyl-3H-imidazol-4-ylmethyl)-2-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | CHEMBL8153 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H38N4O2S |
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| Mol. Mass. | 542.735 |
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| SMILES | Cc1nc[nH]c1CN1C(CCc2ccccc2)CN(Cc2ccccc12)S(=O)(=O)c1ccc(cc1)C(C)(C)C |
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| Structure | 
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