Reaction Details |
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Target | DNA topoisomerase 1 |
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Ligand | BDBM50142516 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_54043 |
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IC50 | >100000±n/a nM |
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Citation | Abdel-Aziz, M; Matsuda, K; Otsuka, M; Uyeda, M; Okawara, T; Suzuki, K Inhibitory activities against topoisomerase I and II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship. Bioorg Med Chem Lett14:1669-72 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA topoisomerase 1 |
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Name: | DNA topoisomerase 1 |
Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 90771.02 |
Organism: | Homo sapiens (Human) |
Description: | P11387 |
Residue: | 765 |
Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
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BDBM50142516 |
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n/a |
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Name | BDBM50142516 |
Synonyms: | Acetic acid 4-[3-(4-acetoxy-benzoylamino)-phenylcarbamoyl]-phenyl ester | CHEMBL296856 |
Type | Small organic molecule |
Emp. Form. | C24H20N2O6 |
Mol. Mass. | 432.4254 |
SMILES | CC(=O)Oc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccc(OC(C)=O)cc2)c1 |
Structure |
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