| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-5 |
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| Ligand | BDBM50142570 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_68415 |
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| Ki | 33±n/a nM |
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| Citation |  Crawforth, J; Atack, JR; Cook, SM; Gibson, KR; Nadin, A; Owens, AP; Pike, A; Rowley, M; Smith, AJ; Sohal, B; Sternfeld, F; Wafford, K; Street, LJ Tricyclic pyridones as functionally selective human GABAA alpha 2/3 receptor-ion channel ligands. Bioorg Med Chem Lett14:1679-82 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit alpha-5 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-5 |
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| Synonyms: | GABA receptor alpha-5 subunit | GABA(A) receptor subunit alpha-5 (GABAAa5) | GABRA5 | GBRA5_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A)) | Gamma-aminobutyric acid receptor subunit alpha-5 (GABAA) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52160.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31644 |
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| Residue: | 462 |
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| Sequence: | MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY
DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL
NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF
PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS
TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM
TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA
KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN
SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
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| BDBM50142570 |
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| n/a |
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| Name | BDBM50142570 |
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| Synonyms: | 9-(4-Methyl-thiazol-2-yl)-11-pyridin-4-yl-6,7-dihydro-5H-2,7a-diaza-dibenzo[a,c]cyclohepten-8-one | CHEMBL45198 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18N4OS |
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| Mol. Mass. | 386.47 |
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| SMILES | Cc1csc(n1)-c1cc(-c2ccncc2)c2-c3cnccc3CCCn2c1=O |
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| Structure | 
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