| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50142892 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106505 (CHEMBL715499) |
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| Ki | 15800±n/a nM |
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| Citation |  Vos, TJ; Caracoti, A; Che, JL; Dai, M; Farrer, CA; Forsyth, NE; Drabic, SV; Horlick, RA; Lamppu, D; Yowe, DL; Balani, S; Li, P; Zeng, H; Joseph, IB; Rodriguez, LE; Maguire, MP; Patane, MA; Claiborne, CF Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J Med Chem47:1602-4 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R_MOUSE | Mc4r |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36964.43 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1498850 |
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| Residue: | 332 |
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| Sequence: | MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVS
GVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTN
MKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPL
IYALRSQELRKTFKEIICFYPLGGICELSSRY
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| BDBM50142892 |
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| n/a |
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| Name | BDBM50142892 |
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| Synonyms: | 2-[2-(2,6-Difluoro-benzylsulfanyl)-phenyl]-1,4,5,6-tetrahydro-pyrimidine | CHEMBL289532 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16F2N2S |
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| Mol. Mass. | 318.384 |
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| SMILES | Fc1cccc(F)c1CSc1ccccc1C1=NCCCN1 |t:18| |
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| Structure | 
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