Reaction Details |
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Target | Potassium voltage-gated channel subfamily KQT member 2 |
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Ligand | BDBM50143559 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_91716 |
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EC50 | 200±n/a nM |
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Citation | Wu, YJ; Boissard, CG; Chen, J; Fitzpatrick, W; Gao, Q; Gribkoff, VK; Harden, DG; He, H; Knox, RJ; Natale, J; Pieschl, RL; Starrett, JE; Sun, LQ; Thompson, M; Weaver, D; Wu, D; Dworetzky, SI (S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons. Bioorg Med Chem Lett14:1991-5 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium voltage-gated channel subfamily KQT member 2 |
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Name: | Potassium voltage-gated channel subfamily KQT member 2 |
Synonyms: | KCNQ2_MOUSE | KQT-like 2 | Kcnq2 | Kqt2 | Potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2 |
Type: | PROTEIN |
Mol. Mass.: | 84494.02 |
Organism: | Mus musculus |
Description: | ChEMBL_990142 |
Residue: | 759 |
Sequence: | MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTG
GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK
SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI
AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF
LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI
GVSFFALPAGILGSGFALKVQEQHRPKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW
QYYERTVTVPMYRLIPPLNQLELLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPR
GMAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRTRQAFRIKGAASRQNSE
EASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDV
IEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPSTPRDKKYPTKGPTAPSRESPQYSPRVDH
IVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIP
PAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRNYAAPPAIPPAQ
CPPSTSWQQSHQRHGTSPVGDHGSLVLRLERSAGMMSCH
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BDBM50143559 |
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n/a |
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Name | BDBM50143559 |
Synonyms: | (E)-N-[1-((S)-4-Ethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide | CHEMBL174891 |
Type | Small organic molecule |
Emp. Form. | C21H23FN2O2 |
Mol. Mass. | 354.4179 |
SMILES | CCN1CCOc2ccc(cc12)[C@H](C)NC(=O)\C=C\c1ccccc1F |
Structure |
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