| Reaction Details |
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 | Report a problem with these data |
| Target | Legumain |
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| Ligand | BDBM50292159 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_96918 (CHEMBL707897) |
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| IC50 | 1000±n/a nM |
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| Citation |  Ekici, OD; Götz, MG; James, KE; Li, ZZ; Rukamp, BJ; Asgian, JL; Caffrey, CR; Hansell, E; Dvorák, J; McKerrow, JH; Potempa, J; Travis, J; Mikolajczyk, J; Salvesen, GS; Powers, JC Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem47:1889-92 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Legumain |
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| Name: | Legumain |
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| Synonyms: | 3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1 |
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| Type: | n/a |
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| Mol. Mass.: | 49411.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 433 |
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| Sequence: | MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
IKLSMDHVCLGHY
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| BDBM50292159 |
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| n/a |
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| Name | BDBM50292159 |
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| Synonyms: | (S)-N'-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-propionyl]-N-carbamoylmethyl-hydrazinecarboxylic acid 2-benzylcarbamoyl-vinyl ester | CHEMBL55249 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32N6O8 |
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| Mol. Mass. | 568.5784 |
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| SMILES | C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NN(CC(N)=O)C(=O)O\C=C\C(=O)NCc1ccccc1 |
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| Structure | 
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