| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50143680 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_924 (CHEMBL615772) |
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| Ki | 1.06±n/a nM |
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| Citation |  Leonardi, A; Barlocco, D; Montesano, F; Cignarella, G; Motta, G; Testa, R; Poggesi, E; Seeber, M; De Benedetti, PG; Fanelli, F Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor. J Med Chem47:1900-18 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
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| Type: | n/a |
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| Mol. Mass.: | 46122.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 422 |
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| Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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| BDBM50143680 |
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| n/a |
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| Name | BDBM50143680 |
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| Synonyms: | 8-{2-[4-(2-Chloro-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decan-7-one | CHEMBL299454 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H30ClN3O |
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| Mol. Mass. | 375.935 |
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| SMILES | Clc1ccccc1N1CCN(CCN2CCC3(CCCC3)CC2=O)CC1 |
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| Structure | 
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