| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50143745 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_39506 (CHEMBL654035) |
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| IC50 | 2.3±n/a nM |
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| Citation |  Thoma, G; Nuninger, F; Schaefer, M; Akyel, KG; Albert, R; Beerli, C; Bruns, C; Francotte, E; Luyten, M; MacKenzie, D; Oberer, L; Streiff, MB; Wagner, T; Walter, H; Weckbecker, G; Zerwes, HG Orally bioavailable competitive CCR5 antagonists. J Med Chem47:1939-55 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50143745 |
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| n/a |
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| Name | BDBM50143745 |
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| Synonyms: | CHEMBL60225 | {4-[Benzyl-(4-bromo-phenyl)-amino]-4'-methyl-[1,4']bipiperidinyl-1'-yl}-(2,6-dimethyl-phenyl)-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C33H40BrN3O |
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| Mol. Mass. | 574.594 |
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| SMILES | Cc1cccc(C)c1C(=O)N1CCC(C)(CC1)N1CCC(CC1)N(Cc1ccccc1)c1ccc(Br)cc1 |
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| Structure | 
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