Reaction Details |
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Target | Cytochrome P450 2D6 |
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Ligand | BDBM50143948 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_51740 |
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Ki | 600±n/a nM |
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Citation | Ashwell, MA; Lapierre, JM; Kaplan, A; Li, J; Marr, C; Yuan, J The design, preparation and SAR of novel small molecule sodium (Na(+)) channel blockers. Bioorg Med Chem Lett14:2025-30 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2D6 |
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Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM50143948 |
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n/a |
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Name | BDBM50143948 |
Synonyms: | 1-Phenoxy-3-{4-[phenyl-(4-trifluoromethyl-phenyl)-methyl]-piperazin-1-yl}-propan-2-ol | CHEMBL60256 |
Type | Small organic molecule |
Emp. Form. | C27H29F3N2O2 |
Mol. Mass. | 470.5266 |
SMILES | OC(COc1ccccc1)CN1CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(F)(F)F |
Structure |
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