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TargetCoagulation factor X
LigandBDBM50144099
Substrate/Competitorn/a
Meas. Tech.ChEBML_48628
IC50 7±n/a nM
Citation Jia, ZJSu, TZuckett, JFWu, YGoldman, EALi, WZhang, PClizbe, LASong, YBauer, SMHuang, WWoolfrey, JSinha, UArfsten, AEHutchaleelaha, AHollenbach, SJLambing, JLScarborough, RMZhu, BY N,N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors. Bioorg Med Chem Lett14:2073-8 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50144099
n/a
NameBDBM50144099
Synonyms:2-{4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-1-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-benzoyl]-piperazin-2-yl}-N,N-dimethyl-acetamide | CHEMBL292305
TypeSmall organic molecule
Emp. Form.C27H30ClN5O4S2
Mol. Mass.588.141
SMILESCN(C)C(=O)CC1CN(CCN1C(=O)c1ccc(cc1)C1=NCCN1C)S(=O)(=O)c1cc2ccc(Cl)cc2s1 |t:22|
Structure
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