| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50144103 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48628 |
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| IC50 | 24±n/a nM |
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| Citation |  Jia, ZJ; Su, T; Zuckett, JF; Wu, Y; Goldman, EA; Li, W; Zhang, P; Clizbe, LA; Song, Y; Bauer, SM; Huang, W; Woolfrey, J; Sinha, U; Arfsten, AE; Hutchaleelaha, A; Hollenbach, SJ; Lambing, JL; Scarborough, RM; Zhu, BY N,N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors. Bioorg Med Chem Lett14:2073-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50144103 |
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| n/a |
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| Name | BDBM50144103 |
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| Synonyms: | CHEMBL417738 | [4-(Azetidin-1-yl-imino-methyl)-phenyl]-[4-(5-chloro-1H-indole-2-sulfonyl)-piperazin-1-yl]-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24ClN5O3S |
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| Mol. Mass. | 485.986 |
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| SMILES | Clc1ccc2[nH]c(cc2c1)S(=O)(=O)N1CCN(CC1)C(=O)c1ccc(cc1)C(=N)N1CCC1 |
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| Structure | 
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