| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta |
|---|
| Ligand | BDBM50144715 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_100168 |
|---|
| IC50 | 28±n/a nM |
|---|
| Citation |  Gong, B; Hong, F; Kohm, C; Jenkins, S; Tulinsky, J; Bhatt, R; De Vries, P; Singer, JW; Klein, P Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta. Bioorg Med Chem Lett14:2303-8 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 1-acyl-sn-glycerol-3-phosphate acyltransferase beta |
|---|
| Name: | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta |
|---|
| Synonyms: | 1-acylglycerol-3-phosphate O-acyltransferase beta | AGPAT2 | PLCB_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30924.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_321473 |
|---|
| Residue: | 278 |
|---|
| Sequence: | MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENM
SIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAK
RELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGD
LLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAAD
VPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
|
|
|
|---|
| BDBM50144715 |
|---|
| n/a |
|---|
| Name | BDBM50144715 |
|---|
| Synonyms: | 2-{4-[2-Amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-ethanol | CHEMBL74708 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21ClN4O2 |
|---|
| Mol. Mass. | 384.859 |
|---|
| SMILES | CCOc1ccc(Cl)cc1-c1cc(Nc2ccc(CCO)cc2)nc(N)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
