| Reaction Details |
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 | Report a problem with these data |
| Target | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta |
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| Ligand | BDBM50144700 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_100168 |
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| IC50 | 16±n/a nM |
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| Citation |  Gong, B; Hong, F; Kohm, C; Jenkins, S; Tulinsky, J; Bhatt, R; De Vries, P; Singer, JW; Klein, P Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta. Bioorg Med Chem Lett14:2303-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1-acyl-sn-glycerol-3-phosphate acyltransferase beta |
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| Name: | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta |
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| Synonyms: | 1-acylglycerol-3-phosphate O-acyltransferase beta | AGPAT2 | PLCB_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30924.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_321473 |
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| Residue: | 278 |
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| Sequence: | MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENM
SIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAK
RELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGD
LLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAAD
VPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
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| BDBM50144700 |
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| n/a |
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| Name | BDBM50144700 |
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| Synonyms: | 6-(5-Bromo-2-ethoxy-phenyl)-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine | CHEMBL310136 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16BrClN4O |
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| Mol. Mass. | 419.703 |
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| SMILES | CCOc1ccc(Br)cc1-c1cc(Nc2ccc(Cl)cc2)nc(N)n1 |
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| Structure | 
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