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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuropeptide Y receptor type 5 | ||
| Ligand | BDBM50145243 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_144155 | ||
| IC50 | 3±n/a nM | ||
| Citation |  Rueeger, H; Gerspacher, M; Buehlmayer, P; Rigollier, P; Yamaguchi, Y; Schmidlin, T; Whitebread, S; Nuesslein-Hildesheim, B; Nick, H; Cricione, L Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett14:2451-7 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuropeptide Y receptor type 5 | |||
| Name: | Neuropeptide Y receptor type 5 | ||
| Synonyms: | NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50746.64 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15761 | ||
| Residue: | 445 | ||
| Sequence: |
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| BDBM50145243 | |||
| n/a | |||
| Name | BDBM50145243 | ||
| Synonyms: | CHEMBL83830 | N,N-dimethyl-N'-({4-[(19-Fluoro-2-methyl-4,5-dihydro-3,6-dithia-1-aza-benzo[e]azulene)amino]cyclohexyl}methyl)-sulfamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H27FN4O2S3 | ||
| Mol. Mass. | 470.647 | ||
| SMILES | CN(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc-2c(CCSc3ccc(F)cc-23)s1 |wU:11.14,wD:8.7,(18.84,-5.25,;17.4,-4.72,;17.13,-3.19,;16.22,-5.71,;15.23,-4.53,;17.2,-6.89,;15.04,-6.7,;13.59,-6.17,;12.4,-7.17,;10.95,-6.64,;9.77,-7.62,;10.03,-9.14,;11.48,-9.67,;12.67,-8.67,;8.84,-10.14,;7.4,-9.61,;6.03,-10.33,;4.93,-9.24,;5.61,-7.85,;4.95,-6.47,;3.45,-6.1,;2.23,-7.03,;2.23,-8.58,;.8,-9.13,;.55,-10.64,;1.74,-11.62,;1.51,-13.15,;3.17,-11.06,;3.4,-9.56,;7.13,-8.09,)| | ||
| Structure | 
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