Reaction Details |
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Target | Neuropeptide Y receptor type 5 |
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Ligand | BDBM50145232 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_144159 |
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IC50 | 2.9±n/a nM |
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Citation | Rueeger, H; Gerspacher, M; Buehlmayer, P; Rigollier, P; Yamaguchi, Y; Schmidlin, T; Whitebread, S; Nuesslein-Hildesheim, B; Nick, H; Cricione, L Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett14:2451-7 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neuropeptide Y receptor type 5 |
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Name: | Neuropeptide Y receptor type 5 |
Synonyms: | NPY-Y5 | NPY5R_RAT | Neuropeptide Y receptor type 5 | Npy5r | Npyr5 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50435.58 |
Organism: | Rat 6B |
Description: | NPY-Y5 NPY5R Rat 6B::Q63634 |
Residue: | 445 |
Sequence: | MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNL
LILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFL
QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL
VELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC
GLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAP
AGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKK
RSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLN
PILYGFLNNGIKADLRALIHCLHMS
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BDBM50145232 |
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n/a |
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Name | BDBM50145232 |
Synonyms: | CHEMBL311229 | {4-[(9-Methyl-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-ylamino)-methyl]-piperidin-1-yl}-(R)-tetrahydro-furan-2-yl-methanone |
Type | Small organic molecule |
Emp. Form. | C23H29N3O3S |
Mol. Mass. | 427.56 |
SMILES | Cc1ccc2OCCc3sc(NCC4CCN(CC4)C(=O)[C@H]4CCCO4)nc3-c2c1 |
Structure |
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