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TargetNeuropeptide Y receptor type 5
LigandBDBM50145232
Substrate/Competitorn/a
Meas. Tech.ChEBML_144159
IC50 2.9±n/a nM
Citation Rueeger, HGerspacher, MBuehlmayer, PRigollier, PYamaguchi, YSchmidlin, TWhitebread, SNuesslein-Hildesheim, BNick, HCricione, L Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett14:2451-7 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuropeptide Y receptor type 5
Name:Neuropeptide Y receptor type 5
Synonyms:NPY-Y5 | NPY5R_RAT | Neuropeptide Y receptor type 5 | Npy5r | Npyr5
Type:Enzyme Catalytic Domain
Mol. Mass.:50435.58
Organism:Rat 6B
Description:NPY-Y5 NPY5R Rat 6B::Q63634
Residue:445
Sequence:
MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNL
LILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFL
QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSL
VELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC
GLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAP
AGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKK
RSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLN
PILYGFLNNGIKADLRALIHCLHMS
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BDBM50145232
n/a
NameBDBM50145232
Synonyms:CHEMBL311229 | {4-[(9-Methyl-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-ylamino)-methyl]-piperidin-1-yl}-(R)-tetrahydro-furan-2-yl-methanone
TypeSmall organic molecule
Emp. Form.C23H29N3O3S
Mol. Mass.427.56
SMILESCc1ccc2OCCc3sc(NCC4CCN(CC4)C(=O)[C@H]4CCCO4)nc3-c2c1
Structure
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