| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1 |
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| Ligand | BDBM50145759 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_51106 (CHEMBL666467) |
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| Ki | 1002±n/a nM |
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| Citation |  Molteni, V; Penzotti, J; Wilson, DM; Termin, AP; Mao, L; Crane, CM; Hassman, F; Wang, T; Wong, H; Miller, KJ; Grossman, S; Grootenhuis, PD N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists. J Med Chem47:2426-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 1 |
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| Name: | Corticotropin-releasing factor receptor 1 |
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| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 50744.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34998 |
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| Residue: | 444 |
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| Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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| BDBM50145759 |
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| n/a |
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| Name | BDBM50145759 |
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| Synonyms: | 1-(2,4-Dichloro-phenylamino)-4-pyridin-4-yl-1-(2-trifluoromethyl-phenyl)-butan-2-one | CHEMBL81262 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17Cl2F3N2O |
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| Mol. Mass. | 453.284 |
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| SMILES | FC(F)(F)c1ccccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 |
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| Structure | 
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